Chlorpyrifos is an organophosphate, neurotoxic pesticide widely used in agriculture. Its neurotoxic effect is due to its ability of inhabiting acetylcholinesterase (AChE), an enzyme needed for the proper functioning of nervous system. Because of its acute toxicity, it is being evaluated by the Stockholm Convention POPs Review Committee (POPRC) which will potentially be listed under POPs and banned globally ( Overview (pops.int) . It is also under evaluation under the Rotterdam Convention Chemicals Review Committee (CRC) for listing in Annex III of the Convention ( Overview (pic.int) ). These concerted efforts are geared towards banning chlorpyrifos. Because of its adverse effects on human health, the environment and other non-target organisms, chlorpyrifos is banned in 39 countries globally. In Ethiopia, chlorpyrifos is allowed only for restrict use. Despite this fact, the chemical is widely available in pesticide shops in rural areas where smallholder farmers are purchasing and usin